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Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging

With ART and the extended lifespan of PLWH, HIV comorbidities also include aging—most likely due to accelerated aging—as well as cardiovascular, neurocognitive disorders, lung and kidney disease, and malignancies. The broad evidence suggests that HIV with ART is associated with accentuated aging and that the age-related comorbidities occur earlier, due in part to chronic immune activation, co-infections, and possibly the effects of ART alone.

Part B: AIDS Drug Assistance Program (ADAP)

Senotherapeutics for HIV and aging

Senescence is a hallmark of aging-related diseases that is characterized by stable cell cycle arrest and chronic inflammation. Chronic HIV-1 infection predisposes patients to aging-related illnesses and is similarly marked by a senescence-like phenotype. A better understanding of the role of HIV-1 in aging will inform the development of therapeutics aimed at eliminating senescent cells that drive accelerated physiologic aging.

Primary Care Guidance for Persons With Human Immunodeficiency Virus: 2020 Update by the HIV Medicine Association of the Infectious Diseases Society of America

To optimize care engagement, medication adherence, and viral suppression, all people with HIV should be provided timely access to care, and HIV care sites should make the effort to provide care in a way that is linguistically and culturally appropriate. HIV care sites should implement programs that incorporate evidence-based programs to improve HIV care engagement and viral suppression.

Maintaining HIV care during the COVID-19 pandemic

Weak healthcare systems have been exposed during the COVID-19 pandemic and challenges have arisen in regard to maintaining HIV care continuum during the COVID-19 pandemic. Particular efforts must focus on ensuring this care to avoid disruption of routine HIV services.

Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study

Co-morbidities and multi-morbidities are extremely prevalent in people living with HIV. More than 50% of PLHW were multi-morbid and about 30% had three or more comorbidities. Those living with HIV are much more at risk of dying or living with more than one disease.

Come as You Are: Improving Care Engagement and Viral Load Suppression Among HIV Care Coordination Clients with Lower Mental Health Functioning, Unstable Housing, and Hard Drug Use

The findings of this study suggest that there is a connection between support to address psychosocial barriers and greater improvement on indicators along the HIV continuum. The findings also aid as evidence to the role of Care Coordination in increasing health and survival opportunities among those who are at the highest risk for suboptimal HIV health outcomes. 

ARTAS – Antiretroviral Treatment Access Study

The Antiretroviral Treatment Access Study (ARTAS) is a strength-based case-management intervention to link recently-diagnosed HIV-positive persons to care and sustain them in care for more than a single visit.

Reconciling the evaluation of co-morbidities among HIV care patients in two large data systems: the Medical Monitoring Project and CFAR Network of Integrated Clinical Systems

Data on persons with HIV and their burden of disease is poor and varies from one database to another. A study was performed utilizing two large databases, MMP and CNICS. The results displayed that each database can provide reliable data to monitor HIV co-morbidities in the US.

A continuum of HIV care describing mortality and loss to follow-up: a longitudinal cohort study

A cross-sectional study assessed how effective it was for those on HIV meds to not transmit to others, along with how high the loss to follow-up was in various HIV programs. They found that there was a high loss of follow-up in HIV care programs, but it highlighted the need for intervention as well as an increase in rates of viral suppression.

Narrowing the Gap in Life Expectancy Between HIV-Infected and HIV-Uninfected Individuals With Access to Care

There is a steep increase in life expectancy for HIV patients who are introduced to ART.  HIV-positive individuals also have a higher prevalence than HIV-uninfected individuals of lifestyle risk factors that should be addressed by providers.