Senotherapeutics for HIV and aging

Szaniawski, M. A., & Spivak, A. M. (2020). Senotherapeutics for HIV and aging. Current Opinion in HIV and AIDS, 15(2), 83–93.

  • Senescence is a hallmark of aging-related diseases that is characterized by stable cell cycle arrest and chronic inflammation. Chronic HIV-1 infection predisposes patients to aging-related illnesses and is similarly marked by a senescence-like phenotype. A better understanding of the role of HIV-1 in aging will inform the development of therapeutics aimed at eliminating senescent cells that drive accelerated physiologic aging.