Advancing HIV, HCV, STIs, LGBTQ health, and drug user health
 
HealthHIV Logo Putting Health First

Inflation Reduction Act Resource Hub

As the Medicare Drug Price Negotiation Program (MDPNP) transforms the prescription drug market, HealthHIV champions the essential needs of patients amid the rollout of negotiated prices for high-cost medications and adjustments by healthcare stakeholders.

The Hub aims to:

  • Safeguard access to life-saving drugs and ensure Medicare beneficiaries can continue receiving necessary treatments.
  • Foster equitable access and affordability through the implementation of negotiated Maximum Fair Prices (MFPs) for selected Medicare drugs.
  • Support vital public health initiatives by addressing potential effects of drug pricing changes on patients, providers, and healthcare systems.
  • Amplify the patient voice in debates over Medicare drug price negotiations and related policies on medication access, affordability, and treatment choices.

What is the Medicare Drug Price Negotiation Program?

The Medicare Drug Price Negotiation Program, established under the Inflation Reduction Act, aims to lower prescription costs for Medicare beneficiaries by negotiating prices for high-cost drugs, making medications more affordable and reducing federal spending. It sets Maximum Fair Prices for certain drugs, negotiated directly with manufacturers by CMS. Starting in 2026, these prices apply to Medicare Part D drugs, with more drugs included later. The program could impact formulary design, care workflows, administrative tasks, and treatment continuity, especially for older adults with multiple conditions. Input from providers, especially those delivering HIV care, is vital, as stable access influences medication adherence, quality of life, and understanding of unmet medical needs in negotiations.


What’s at stake for patients?
  • Affordability, from a patient perspective, means being able to access essential medications and treatments without facing financial hardship. The program is intended to reduce prescription drug costs for people with Medicare and improve access to needed medications.
  • Access and continuity of care are important considerations as negotiated prices are implemented. The program applies to selected high-cost drugs covered by Medicare, and patients may benefit from lower out-of-pocket costs when a negotiated MFP applies to their medication. Patient protections and continued access to medically necessary treatments remain important as the program evolves.
What’s at stake for providers?
  • For providers, it may affect prescribing decisions, patient counseling, and the affordability of selected medications for Medicare beneficiaries. Providers remain focused on delivering high-quality, evidence-based care while helping patients navigate prescription drug costs.
  • Providers may need to understand how negotiated MFPs affect selected drugs covered by Medicare and how those prices may influence patients’ out-of-pocket costs. While the program does not require providers to substitute a negotiated drug with another medication, providers may need to help patients understand their coverage, costs, and available treatment options.
  • Providers who are 340B-eligible covered entities could experience lower revenue through margin compression, overlapping pricing rules, and lower reimbursements.
What’s at stake for payers?
  • Payers work to balance controlling prescription drug spending with ensuring that patients have equitable access to medically necessary medications. The program introduces negotiated MFPs for selected high-cost drugs covered by Medicare, with the goal of reducing costs for beneficiaries and the Medicare program.
  • Medicare plans and other stakeholders must navigate changes in drug pricing, reimbursement, and benefit administration as negotiated prices take effect. For Medicare Part D plans, the program may affect drug spending, plan costs, and beneficiary cost-sharing for selected drugs. Plans must also account for applicable Medicare requirements when managing formularies and coverage for negotiated drugs.

Learn More

The Centers for Medicare and Medicaid Services has announced the selection of a widely used HIV treatment for Medicare price negotiation under IPAY2028 as part of the Inflation Reduction Act.
For our community, this issue is not abstract.
This is a critical time to share your experience.

Here’s What You Need to Know Now:

2028 IPAY Medicare Drug Price Negotiation Program public engagement process: CMS is negotiating prices for 15 drugs and is inviting patients, advocates, and providers to share real-world experience with these medications. Input from people affected by HIV—and those who care for them—can directly inform these negotiations.

The links below provide practical tools to help you prepare, understand, and make the most of these opportunities.

Medicare Annual Open Enrollment Period

Medicare’s Annual Open Enrollment Period runs from October 15 through December 7.

This period affords beneficiaries a one-year opportunity to review and make changes to their prescription drug coverage for 2027.

2027 Open Enrollment Resources

Access Considerations for People Aging with HIV: IRA Negotiations and BIKTARVY®

The Centers for Medicare and Medicaid Services recently selected 15 Medicare-covered drugs for the third cycle of Medicare drug price negotiation, known as IPAY 2028, under the Inflation Reduction Act.

BIKTARVY (bictegravir, emtricitabine, and tenofovir alafenamide), a widely used single-tablet HIV treatment regimen, is one of the selected drugs.

This fact sheet provides information and considerations on these negotiations.

Learn More

Related Health Policy Resources

Browse All Resources

Additional Resources

Drug Affordability in Practice: Who Saves, Who Pays, and What Happens to Access?

Join HealthHIV and its partners—AiArthritis, the Partnership to Improve Patient Care (PIPC), the Partnership for Safe Medicines, and the Rare Access Action Project (RAAP)—for a webinar that will examine where savings are anticipated to occur, who likely benefits, and how payment decisions can impact: coverage, reimbursement, benefit design, provider and pharmacy practices, patient assistance programs, and out-of-pocket costs.

When Cost-Cutting Undermines HIV Care—The Case for Single-Tablet Regimens

Op-Ed in PositivelyAware, April 21, 2026

Unmet Medical Need Comments

Comments by HealthHIV, July 3, 2025.

Medicare Drug Price Negotiation Program Draft Guidance Comments (IPAY 2027)

Comments by HealthHIV, July 2, 2024.

Medicare Drug Price Negotiation Program Draft Guidance Comments (IPAY 2028)

Comments by HealthHIV, April 8, 2026.

On your time. In your space.

HealthHIV

1630 Connecticut Ave. NW
Suite 500
Washington, DC 20009

202-232-6749
[email protected]

Connect

Get the latest training opportunities, news, and more delivered directly to your inbox.

Get Updates
 

© Copyright 2026 HealthHIV. All rights reserved. | Privacy Policy | Site Map | About
HealthHIV is a 501(c)(3) organization. Donations are tax-deductible to the extent permitted by law. EIN: 52-2253960