Oral and Gut Microbial Diversity and Immune Regulation in Patients with HIV on Antiretroviral Therapy

Annavajhala, M. K., Khan, S. D., Sullivan, S. B., Shah, J., Pass, L., Kister, K., Kunen, H., Chiang, V., Monnot, G. C., Ricupero, C. L., Mazur, R. A., Gordon, P., de Jong, A., Wadhwa, S., Yin, M. T., Demmer, R. T., & Uhlemann, A. C. (2020). Oral and Gut Microbial Diversity and Immune Regulation in Patients with HIV on Antiretroviral Therapy. mSphere, 5(1), e00798-19.

https://healthhiv.org/wp-content/uploads/2022/09/Annavajhala-M.-K.-Khan-S.-D.pdf

The study aimed to determine the relationship between oral and gut microbiome diversity and chronic systemic inflammation in ART-treated PLWH with prevalent severe periodontitis, an inflammatory condition commonly associated with HIV infection. The results indicate that interventions targeting both inflammation and microbial diversity are needed to mitigate oral inflammation-related comorbidities, particularly in HIV-positive patients.