Ancona, G., Merlini, E., Tincati, C., Barassi, A., Calcagno, A., Augello, M., Bono, V., Bai, F., Cannizzo, E. S., d’Arminio Monforte, A., & Marchetti, G. (2021). Long-Term Suppressive cART Is Not Sufficient to Restore Intestinal Permeability and Gut Microbiota Compositional Changes. Frontiers in immunology, 12, 639291.
https://healthhiv.org/wp-content/uploads/2022/09/Ancona-G.-Merlini-E..pdf
The study explores the long-term effects of cART on markers of gut damage, microbial translocation, and paired gut/blood microbiota composition, with a focus on the role exerted by different drug classes. The results conclude that 24 months of cART only affects the gastrointestinal tract minorly.
