Senotherapeutics for HIV and aging
Senescence is a hallmark of aging-related diseases that is characterized by stable cell cycle arrest and chronic inflammation. Chronic HIV-1 infection predisposes patients to aging-related illnesses and is similarly marked by a senescence-like phenotype. A better understanding of the role of HIV-1 in aging will inform the development of therapeutics aimed at eliminating senescent cells that drive accelerated physiologic aging.
Long-Term Suppressive cART Is Not Sufficient to Restore Intestinal Permeability and Gut Microbiota Compositional Changes
The study explores the long-term effects of cART on markers of gut damage, microbial translocation, and paired gut/blood microbiota composition, with a focus on the role exerted by different drug classes.
Altered gut microbiota correlates with different immune responses to HAART in HIV-infected individuals
Gut microbiota and immune activation were studied in 36 non-HIV-infected subjects and 58 HIV-infected individuals, including 28 immunological responders and 30 immunological non-responders without comorbidities.
The Current State of HIV and Aging: Findings Presented at the 10th International Workshop on HIV and Aging
This article summarizes plenary talks from the 10th Annual International Workshop on HIV and Aging, which took place in New York City on October 10 and 11, 2019. Presentation topics included the following: the burdens of HIV-associated comorbidities, aging phenotypes, community engagement, and loneliness; these issues are especially important for older PWH, considering the COVID-19 pandemic.
Primary Care Guidance for Persons With Human Immunodeficiency Virus: 2020 Update by the HIV Medicine Association of the Infectious Diseases Society of America
To optimize care engagement, medication adherence, and viral suppression, all people with HIV should be provided timely access to care, and HIV care sites should make the effort to provide care in a way that is linguistically and culturally appropriate. HIV care sites should implement programs that incorporate evidence-based programs to improve HIV care engagement and viral suppression.
Echocardiographic Findings Among Virally Suppressed HIV-Infected Aging Asians Compared with HIV-Negative Individuals
The study looked into the prevalence and risk factors associated with echocardiogram abnormalities among those who are older and living with HIV.
Evaluation of a combined HIV and geriatrics clinic for older people living with HIV: The Silver Clinic in Brighton, UK
In an evaluated clinic that worked with aging PLWH, it was found that almost all referrals to the clinic involved comorbidities and suspected geriatric syndrome. Researchers suggested that Geriatricians with specializations in HIV might soon play a key role in the management and care of older people with both HIV and geriatric syndromes.
New York Guidance for Addressing the Needs of Older Patients in HIV Care
New York Department of Health AIDS Institute: Guidance for Addressing the Needs of Older Patients in HIV Care. The goals include: Raising clinicians’ awareness of the needs and concerns of patients with HIV who are 50 or older; Inform clinicians about an aging-related approach to older patients with HIV; Offering recommendations to help clinicians provide optimal care for this population; Provide resources about aging with HIV for healthcare providers and their patients; Suggest steps to guide medical settings in implementing geriatric care into HIV clinical practice.
Coronavirus disease 2019 (COVID-19) outcomes in HIV/AIDS patients: A systematic review
This study worked to see the outcome of those who are living with AIDS and who also contracted COVID-19. They concluded that those with HIV/AIDS who had the disease well-controlled were not at a higher risk of COVID-19 symptoms being more severe. It was also found that those with bacterial pneumonia may be at risk of worse COVID-19 symptoms.
Research priorities for rehabilitation and aging with HIV: a framework from the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC)
People with HIV are living longer and can experience physical, mental, and social health challenges associated with aging and multimorbidity. Rehabilitation is well-positioned to address disability and maximize healthy aging. In this article, findings from CIHRRC’s aim to identify emerging research priorities in HIV, aging, and rehabilitation from the perspectives of people living with HIV, clinicians, researchers, representatives from community organizations, and policy stakeholders are reported.
